A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumor Consortium (NABTC01-05) Academic Article uri icon

Overview

MeSH Major

  • Carboxymethylcellulose Sodium
  • Glioblastoma
  • Interferon Inducers
  • Poly I-C
  • Polylysine
  • Radiotherapy
  • Supratentorial Neoplasms

abstract

  • The combined therapy was relatively well-tolerated. This study suggests a survival advantage compared to historical studies using RT without chemotherapy but no survival advantage compared to RT with adjuvant nitrosourea or non-temozolomide chemotherapy. Our results suggest that poly-ICLC has activity against glioblastoma and may be worth further study in combination with agents such as temozolomide.

publication date

  • January 2009

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4779120

Digital Object Identifier (DOI)

  • 10.1007/s11060-008-9693-3

PubMed ID

  • 18797818

Additional Document Info

start page

  • 175

end page

  • 82

volume

  • 91

number

  • 2