NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells
Academic Article
Overview
MeSH Major
Antineoplastic Agents
Apoptosis
Camptothecin
Cell Proliferation
Prostatic Neoplasms
abstract
The data obtained suggest that NSC is able to decrease cell growth, induce cell apoptosis and cause growth arrest in prostatic tumor cells, which may involve an interaction with topoisomerase 1 and an activation of mitochondrial apoptotic pathway.
