Chemistry and biology of diazonamide A: Second total synthesis and biological investigations Academic Article uri icon

Overview

MeSH Major

  • Heterocyclic Compounds, 4 or More Rings
  • Oxazoles

abstract

  • As an especially unique target for chemical synthesis, diazonamide A has the potential to be constructed through a plethora of synthetic routes, each attended by different challenges and opportunities for discovery. In this article, we detail our second total synthesis of diazonamide A through a sequence entirely distinct from that employed in our first campaign, one whose success required the development of several special strategies and tactics. We also disclose our complete studies regarding the chemical biology of diazonamide A and its structural congeners, and more fully delineate the scope of our protocol for Robinson-Gabriel cyclodehydration using pyridine-buffered POCl(3).

publication date

  • October 13, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 15469287

Additional Document Info

start page

  • 12897

end page

  • 906

volume

  • 126

number

  • 40