Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity Academic Article uri icon

Overview

MeSH Major

  • Brain-Derived Neurotrophic Factor
  • Fibrinolysin
  • Hippocampus
  • Long-Term Potentiation
  • Synapses
  • Tissue Plasminogen Activator

abstract

  • Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.

publication date

  • October 15, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1100135

PubMed ID

  • 15486301

Additional Document Info

start page

  • 487

end page

  • 91

volume

  • 306

number

  • 5695