Following the cytokine signaling pathway to leukemogenesis: A chronology Review uri icon


MeSH Major

  • Cell Physiological Phenomena
  • Cytokines
  • Leukemia
  • Signal Transduction


  • Studies over the past 50 years revealing the molecular events that promote normal T lymphocyte cycle competence and progression led to a detailed understanding of how cytokines function to regulate normal hematopoietic cell proliferation. During that same period, the molecular and genetic changes introduced by the Philadelphia chromosome in chronic myelogenous leukemia were unraveled, and these have led to an understanding of how mutations that constitutively activate normal cytokine signaling pathways can cause unregulated cell proliferation and malignant transformation. Based on the paradigm established by these data, it is inescapable that going forward, investigators will operate under the hypothesis that transformation of additional cells and tissues will have a similar pathogenesis.

publication date

  • November 3, 2008



  • Review



  • eng

PubMed Central ID

  • PMC2575728

Digital Object Identifier (DOI)

  • 10.1172/JCI35819

PubMed ID

  • 18982163

Additional Document Info

start page

  • 3564

end page

  • 73


  • 118


  • 11