Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish
Bone Morphogenetic Proteins
Hematopoietic Stem Cells
Our study provides proof of principle that regulation of adult hematopoiesis can be studied in zebrafish by altering specific pathways. We show that the BMP signaling pathway is relevant for adult hematopoiesis to maintain steady state erythropoiesis, control the erythropoietic response following stress anemia, and to generate normal numbers of eosinophils.