Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish Academic Article uri icon

Overview

MeSH Major

  • Bone Morphogenetic Proteins
  • Erythropoiesis
  • Hematopoietic Stem Cells
  • Signal Transduction
  • Smad5 Protein
  • Zebrafish
  • Zebrafish Proteins

abstract

  • Our study provides proof of principle that regulation of adult hematopoiesis can be studied in zebrafish by altering specific pathways. We show that the BMP signaling pathway is relevant for adult hematopoiesis to maintain steady state erythropoiesis, control the erythropoietic response following stress anemia, and to generate normal numbers of eosinophils.

publication date

  • December 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2602881

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2008.08.005

PubMed ID

  • 18973974

Additional Document Info

start page

  • 1604

end page

  • 1615

volume

  • 36

number

  • 12