Hippocampal structural changes across the menstrual cycle. Academic Article uri icon

Overview

MeSH

  • Adult
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Neuronal Plasticity
  • Premenstrual Syndrome

MeSH Major

  • Brain Mapping
  • Hippocampus
  • Memory
  • Menstrual Cycle
  • Verbal Learning

abstract

  • Magnetic resonance imaging (MRI) in association with Jacobian-modulated voxel-based morphometry (VBM) was used to test for regional variation in gray matter over the menstrual cycle. T1-weighted anatomical images were acquired using a spoiled gradient recalled acquisition sequence in 21 women. Each subject was scanned twice: once during the postmenstrual late-follicular phase (Days 10-12 after onset of menses), and once during the premenstrual late-luteal phase (1-5 days before the onset of menses). Gray matter was relatively increased in the right anterior hippocampus and relatively decreased in the right dorsal basal ganglia (globus pallidus/putamen) in the postmenstrual phase. Verbal declarative memory was increased in the postmenstrual vs. premenstrual phase. This first report of human brain structural plasticity associated with the endogenous menstrual cycle extends well-established animal findings of hormone-mediated hippocampal plasticity to humans, and has implications for understanding alterations in cognition and behavior across the menstrual cycle.

publication date

  • 2008

has subject area

  • Adult
  • Brain Mapping
  • Female
  • Hippocampus
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Memory
  • Menstrual Cycle
  • Neuronal Plasticity
  • Premenstrual Syndrome
  • Verbal Learning

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/hipo.20468

PubMed ID

  • 18767068

Additional Document Info

start page

  • 985

end page

  • 988

volume

  • 18

number

  • 10