Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction-staged sentinel lymph nodes from melanoma patients Academic Article uri icon

Overview

MeSH Major

  • Melanoma
  • Monophenol Monooxygenase
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sentinel Lymph Node Biopsy
  • Skin Neoplasms

abstract

  • With extended follow-up of patients with histologically negative SLNs, detection of submicroscopic disease by tyrosinase RT-PCR does not define a subgroup that is at higher recurrence risk when compared with patients with RT-PCR-negative SLNs. Future studies evaluating molecular staging will require approximately 5 years of median follow-up to accurately define outcome for patients with occult melanoma metastases.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2004.03.052

PubMed ID

  • 15459222

Additional Document Info

start page

  • 3989

end page

  • 96

volume

  • 22

number

  • 19