Del(6)(q22) and BCL6 rearrangements in primary CNS lymphoma are indicators of an aggressive clinical course Academic Article uri icon

Overview

MeSH Major

  • Central Nervous System Neoplasms
  • Chromosomes, Human, Pair 6
  • DNA-Binding Proteins
  • Lymphoma, Non-Hodgkin

abstract

  • Del (6)(q22) and BCL6 rearrangements are common in PCNSL and predict for decreased OS independent of deep structure involvement and HDMTX. Unlike systemic diffuse large B-cell lymphoma, del(6)(q22) is common and IGH translocations are infrequent and usually involve BCL6 rather than BCL2, suggesting a distinct pathogenesis.

publication date

  • October 10, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2653136

Digital Object Identifier (DOI)

  • 10.1200/JCO.2008.16.1455

PubMed ID

  • 18645192

Additional Document Info

start page

  • 4814

end page

  • 9

volume

  • 26

number

  • 29