Conformational analysis of longifolene Academic Article uri icon

Overview

MeSH Major

  • Pulmonary Disease, Chronic Obstructive
  • Smoking
  • Wnt Proteins
  • beta Catenin

abstract

  • We describe the stable conformation of the tricyclic sesquiterpenoid, longifolene, by experimental NMR data and molecular mechanics calculations of the coupling constants. The flexible seven-membered ring of longifolene adopts a twist-chair conformation. Analysis of the coupling constants, particularly of the methylene protons in the cycloheptane ring moiety, agrees with this low-energy conformation. Low-temperature NMR experiments and nuclear Overhauser effect measurements indicate that there is a single exchange-averaged NMR spectrum that has the highest population of the most stable conformer. Copyright © Taylor & Francis Group, LLC.

publication date

  • October 2008

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1080/00387010802371528

Additional Document Info

start page

  • 349

end page

  • 353

volume

  • 41

number

  • 7