JAK2 and MPL mutations in myeloproliferative neoplasms: Discovery and science Review uri icon

Overview

MeSH Major

  • Janus Kinase 2
  • Mutation
  • Polycythemia Vera
  • Primary Myelofibrosis
  • Receptors, Thrombopoietin
  • Thrombocythemia, Essential

abstract

  • Although it has long been known that the myeloproliferative neoplasms (MPN) polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are clonal hematopoietic stem-cell disorders, for many years the genetic basis for these disorders was elusive. A new era in MPN biology began in 2005 with the discovery of a somatic point mutation in JAK2 tyrosine kinase (JAK2V617F), which was identified in a significant proportion of patients with PV, ET and PMF. Based on the hypothesis that JAK-STAT signaling is central to the pathogenesis of JAK2V617F-negative MPN, genomic studies have identified JAK2 exon 12 mutations in JAK2V617F-negative PV and activating mutations in MPL in patients with JAK2V617F-negative ET and PMF. In this review, we will discuss the role of these mutant alleles in the pathogenesis of PV, ET and PMF, the potential therapeutic implications of these discoveries, and the implications of these discoveries for genomic studies of hematopoietic malignancies.

publication date

  • August 29, 2008

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/leu.2008.229

PubMed ID

  • 18754026

Additional Document Info

start page

  • 1813

end page

  • 7

volume

  • 22

number

  • 10