Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion Academic Article uri icon

Overview

MeSH Major

  • Autonomic Nervous System
  • Blood Pressure
  • Chromogranin A
  • Genetic Variation
  • Hypertension

abstract

  • Common variant C+87T in the CHGA 3'-UTR is a functional polymorphism causally associated with hypertension especially in men of the population, and we propose steps ("intermediate phenotypes") whereby in a sex-dependent fashion this genetic variant influences the ultimate disease trait. These observations suggest new molecular strategies to probe the pathophysiology, risk, and rational treatment of hypertension.

publication date

  • October 28, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2659417

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2008.07.047

PubMed ID

  • 19017515

Additional Document Info

start page

  • 1468

end page

  • 81

volume

  • 52

number

  • 18