Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease Academic Article uri icon

Overview

MeSH Major

  • Autophagy
  • Early Growth Response Protein 1
  • Pulmonary Disease, Chronic Obstructive
  • Smoking
  • Tobacco

abstract

  • We demonstrate a critical role for Egr-1 in promoting autophagy and apoptosis in response to cigarette smoke exposure in vitro and in vivo. The induction of autophagy at early stages of COPD progression suggests novel therapeutic targets for the treatment of cigarette smoke induced lung injury.

publication date

  • October 2, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2552992

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0003316

PubMed ID

  • 18830406

Additional Document Info

start page

  • e3316

volume

  • 3

number

  • 10