The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease Academic Article uri icon

Overview

MeSH Major

  • Complement C3d
  • Complement C4b
  • Dermatitis
  • Fluorescent Antibody Technique, Direct
  • Immunohistochemistry
  • Peptide Fragments

abstract

  • When correlated with the light microscopic and clinical findings, the C3d and C4d assay has significant application in the assessment of select inflammatory skin diseases including vasculopathic conditions, collagen vascular disease, and autoimmune vesiculobullous disorder. It may prompt further DIF testing or, in some instances, may even define a reasonable substitute for DIF and/or add to the morphologic assessment of a biopsy specimen submitted for routine light microscopic assessment primarily in the setting of autoimmune vesiculobullous disease and collagen vascular disease.

publication date

  • November 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2008.06.022

PubMed ID

  • 19119098

Additional Document Info

start page

  • 822

end page

  • 33

volume

  • 59

number

  • 5