Seeding and propagation of untransformed mouse mammary cells in the lung Academic Article uri icon

Overview

MeSH Major

  • Epithelial Cells
  • Lung Neoplasms
  • Mammary Glands, Animal
  • Neoplasm Metastasis
  • Neoplasm Seeding
  • Oncogenes

abstract

  • The acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. We report that untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and Kras(D12), or polyoma middle T, and introduced into the systemic circulation of a mouse can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the bloodstream and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors.

publication date

  • September 26, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2694414

Digital Object Identifier (DOI)

  • 10.1126/science.1161621

PubMed ID

  • 18755941

Additional Document Info

start page

  • 1841

end page

  • 4

volume

  • 321

number

  • 5897