Accelerated control of visceral Leishmania donovani infection in interleukin-6-deficient mice Academic Article uri icon

Overview

MeSH Major

  • Interleukin-6
  • Leishmania donovani
  • Leishmaniasis, Visceral

abstract

  • In patients with visceral leishmaniasis, increased levels of circulating interleukin-6 (IL-6) regularly accompany fully expressed, progressive infections (kala-azar). To experimentally test the role of IL-6, responses to an intracellular Leishmania donovani infection in the livers of IL-6(-/-) and wild-type mice were compared. IL-6(-/-) mice showed an enhanced control of the infection and earlier, rapid parasite killing along with additional evidence of a stimulated antileishmanial Th1-cell-type response: increased levels of circulating gamma interferon, accelerated granuloma assembly, and heightened responsiveness to chemotherapy. In this model of visceral leishmaniasis, IL-6 appears to act in a suppressive, macrophage-deactivating fashion, which identifies it as a potential target for therapeutic blockade.

publication date

  • September 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2519417

Digital Object Identifier (DOI)

  • 10.1128/IAI.00490-08

PubMed ID

  • 18573898

Additional Document Info

start page

  • 4088

end page

  • 91

volume

  • 76

number

  • 9