Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis Academic Article uri icon

Overview

MeSH Major

  • Antifungal Agents
  • Candidiasis, Vulvovaginal
  • Fluconazole
  • Mannose-Binding Lectin
  • Polymorphism, Genetic

abstract

  • The MBL2 codon 54 gene polymorphism is more frequent in Belgian women suffering from RVC than in controls. The presence of the B allele is associated with a superior response to fluconazole maintenance therapy as compared with RVC patients without this polymorphism. We conclude that RVC due to deficient MBL production is more easily helped with antifungal medication than is RVC due to some other mechanism.

publication date

  • September 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1471-0528.2008.01830.x

PubMed ID

  • 18715406

Additional Document Info

start page

  • 1225

end page

  • 31

volume

  • 115

number

  • 10