Noninvasive prediction of organ graft rejection and outcome using gene expression patterns Review uri icon

Overview

MeSH Major

  • Gene Expression Profiling
  • Graft Rejection

abstract

  • Development of predictive, diagnostic, and prognostic biomarkers of allograft status and outcome is important and challenging, and may be rewarded with individualized therapy for the organ graft recipient. Herein, we summarize noninvasive messenger RNA profiling studies for ascertaining allograft status and outcome. Nucleic acid-based biomarkers of allograft status have been developed by several laboratories, but the studies have primarily been single center investigations. Ongoing multicenter trials including the Clinical Trials in Organ Transplantation (https://www.ctotstudies.org) should help further to define the clinical utility of noninvasively developed messenger RNA profiles as biomarkers of allograft status and outcome.

publication date

  • July 27, 2008

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3595195

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e31817eef7b

PubMed ID

  • 18645476

Additional Document Info

start page

  • 192

end page

  • 9

volume

  • 86

number

  • 2