Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Lung Neoplasms

abstract

  • Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas. The hypotheses proposed examined whether microarray measurements of gene expression either alone or combined with basic clinical covariates (stage, age, sex) could be used to predict overall survival in lung cancer subjects. Several models examined produced risk scores that substantially correlated with actual subject outcome. Most methods performed better with clinical data, supporting the combined use of clinical and molecular information when building prognostic models for early-stage lung cancer. This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas.

authors

publication date

  • August 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2667337

Digital Object Identifier (DOI)

  • 10.1038/nm.1790

PubMed ID

  • 18641660

Additional Document Info

start page

  • 822

end page

  • 7

volume

  • 14

number

  • 8