Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Type 2
  • Genetic Predisposition to Disease
  • Heterotrimeric GTP-Binding Proteins
  • Polymorphism, Single Nucleotide
  • Sodium Chloride, Dietary

abstract

  • The associations of the C825T polymorphism (rs5443) of the G-protein beta3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0+/-10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p=0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n=1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006).

publication date

  • September 26, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.bbrc.2008.07.065

PubMed ID

  • 18656447

Additional Document Info

start page

  • 576

end page

  • 80

volume

  • 374

number

  • 3