Pathophysioloy and treatment of painful diabetic neuropathy Article Report uri icon


MeSH Major

  • Cornea
  • Microscopy, Confocal
  • Nerve Fibers
  • Peripheral Nervous System Diseases


  • Diabetes is the most common cause of peripheral neuropathy, and painful diabetic neuropathy (PDN) affects approximately 30% of diabetic patients with neuropathy. It is extremely distressing for the patient and poses significant management difficulties because no treatment provides total relief, and side effects of therapy are a major limiting factor for titrating therapy. Understanding the pathogenesis of diabetic neuropathy may lead to the development of new treatments to prevent nerve damage, and a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. We provide an update on the pathogenesis, diagnosis, and treatment of PDN.

publication date

  • June 2008



  • Report


Digital Object Identifier (DOI)

  • 10.1007/s11916-008-0034-1

PubMed ID

  • 18796269

Additional Document Info

start page

  • 192

end page

  • 7


  • 12


  • 3