Whither or wither microbicides? Academic Article uri icon

Overview

MeSH Major

  • Anti-HIV Agents
  • Anti-Infective Agents, Local
  • HIV Infections
  • HIV-1
  • Polymers
  • Reverse Transcriptase Inhibitors
  • Vaginal Diseases

abstract

  • After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.

publication date

  • July 25, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2835691

Digital Object Identifier (DOI)

  • 10.1126/science.1160355

PubMed ID

  • 18653884

Additional Document Info

start page

  • 532

end page

  • 534

volume

  • 321

number

  • 5888