Pharmacokinetics and tolerability of exemestane in combination with raloxifene in postmenopausal women with a history of breast cancer Academic Article uri icon

Overview

MeSH Major

  • Androstadienes
  • Aromatase Inhibitors
  • Breast Neoplasms
  • Raloxifene Hydrochloride
  • Selective Estrogen Receptor Modulators

abstract

  • In this small study, coadministration of raloxifene and exemestane did not affect the pharmacokinetics or pharmacodynamics of either agent to a significant degree in postmenopausal women. The combination of estrogen receptor blockade and suppression of estrogen synthesis is well tolerated and warrants further investigation.

publication date

  • September 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s10549-007-9787-1

PubMed ID

  • 17952589

Additional Document Info

start page

  • 377

end page

  • 88

volume

  • 111

number

  • 2