Ionizing radiation of mesenchymal stem cells results in diminution of the precursor pool and limits potential for multilineage differentiation Academic Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Cell Proliferation
  • Mesenchymal Stromal Cells
  • Radiation, Ionizing

abstract

  • Although the majority of mesenchymal stem cells survive injury from ionizing radiation, this injury results in a significant decrease in cellular proliferation. Furthermore, the differentiation potential of irradiated mesenchymal stem cells in response to environmental stimuli is markedly diminished. Thus, the negative effects of ionizing radiation may result from a decreased pool of progenitor cells with limited differentiation potential. Proposed radioprotection strategies aiming to reduce tissue injury should therefore evaluate not only cellular survival but also cellular function.

publication date

  • July 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/PRS.0b013e31817743cd

PubMed ID

  • 18594388

Additional Document Info

start page

  • 64

end page

  • 76

volume

  • 122

number

  • 1