OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ tregs Academic Article uri icon

Overview

MeSH Major

  • CD40 Ligand
  • Forkhead Transcription Factors
  • Graft Rejection
  • Graft Survival
  • Islets of Langerhans Transplantation
  • Membrane Glycoproteins
  • Tumor Necrosis Factors

abstract

  • The role of OX40 in the islet allograft tolerance, especially in the absence of CD154 costimulation, remains poorly defined. In the present study, we used CD154 deficient mice to critically examine the role of OX40 in the activation of T effector cells and Foxp3+ Tregs and the effect of blocking OX40 on the induction of islet allograft tolerance. We found that blocking OX40 costimulation in CD154 deficient mice induced donor specific tolerance but stimulating OX40 resulted in prompt islet allograft rejection. We also found that OX40 differentially regulates T effector cells and Foxp3+ Tregs, OX40 signaling mediates proliferation of CD154 deficient T effector cells but blocks the induction and suppressor functions of Foxp3+ Tregs. Our data suggest that the role of OX40 in the induction of islet allograft tolerance involves modifying not only the T effector cells but also the Foxp3+ Tregs in CD154 deficient mice.

publication date

  • June 15, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e3181726987

PubMed ID

  • 18551075

Additional Document Info

start page

  • 1659

end page

  • 62

volume

  • 85

number

  • 11