Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1 Academic Article uri icon

Overview

MeSH Major

  • DNA-Binding Proteins
  • SARS Virus
  • Severe Acute Respiratory Syndrome
  • Trans-Activators

abstract

  • Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

publication date

  • October 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC521834

Digital Object Identifier (DOI)

  • 10.1128/JVI.78.20.11416-11421.2004

PubMed ID

  • 15452265

Additional Document Info

start page

  • 11416

end page

  • 21

volume

  • 78

number

  • 20