Liposome-mediated transfer of nitric oxide synthase gene improves renal function in ureteral obstruction in rats Academic Article uri icon

Overview

MeSH Major

  • Genetic Therapy
  • Kidney
  • Nitric Oxide Synthase
  • Ureteral Obstruction

abstract

  • This study demonstrates the feasibility of liposome-mediated iNOS gene transfer into the kidney. Furthermore, the improvement of renal function in UUO demonstrates that the transfected iNOS gene is active and suggests that decreased iNOS activity contributes to the decreased renal function in UUO. This iNOS construct may have therapeutic utility in the pathophysiologic sequelae of UUO and other renal diseases.

publication date

  • October 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1523-1755.2004.00899.x

PubMed ID

  • 15458429

Additional Document Info

start page

  • 1365

end page

  • 75

volume

  • 66

number

  • 4