Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin Academic Article uri icon

Overview

MeSH Major

  • Cancer Vaccines
  • Carcinoma, Small Cell
  • G(M1) Ganglioside
  • Hemocyanin
  • Immunotherapy
  • Lung Neoplasms

abstract

  • Vaccination with the synthetic fucosyl GM1-KLH conjugate induces an IgM antibody response against fucosyl GM1 and tumor cells expressing fucosyl GM1, comparable with the response induced by the bovine derivative. We plan to combine synthetic fucosyl GM1 vaccine at a dose of 30 microg with vaccines against three other antigens-GM2, Globo H, and polysialic acid-to test in patients with SCLC after initial chemotherapy.

publication date

  • September 15, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-04-0482

PubMed ID

  • 15447995

Additional Document Info

start page

  • 6094

end page

  • 100

volume

  • 10

number

  • 18 I