Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids Article Report uri icon

Overview

MeSH Major

  • Mesothelioma
  • Pleural Neoplasms

abstract

  • This paper presents several lines of evidence against the proposed link between SV40 infection and human mesotheliomas. Studies reporting a high prevalence of SV40 DNA in human tumours have been based on molecular assays prone to false-positive results. Because SV40 appears unlikely to have a major role, if any, in human mesotheliomas, clinicians should continue to consider asbestos exposure as the most likely and most thoroughly established aetiological factor in individuals with this cancer.

publication date

  • September 25, 2004

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(04)17102-X

PubMed ID

  • 15451223

Additional Document Info

start page

  • 1157

end page

  • 66

volume

  • 364

number

  • 9440