Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Clinical Trials as Topic
  • Cohort Studies
  • Combined Modality Therapy
  • Cyclophosphamide
  • Databases, Factual
  • Dexamethasone
  • Disease-Free Survival
  • Doxorubicin
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prednisone
  • Radiotherapy
  • Regression Analysis
  • Retrospective Studies
  • Rituximab
  • Survival Analysis
  • Time Factors
  • Transplantation, Autologous
  • Treatment Outcome
  • Vincristine

MeSH Major

  • Biomarkers, Tumor
  • Lymphoma, Mantle-Cell
  • Stem Cell Transplantation

abstract

  • Reported median overall survival (OS) in patients with mantle cell lymphoma (MCL) has been reported to be just 3-4 years. As a consequence, first-line treatment has become more aggressive. Single-center studies with R-Hyper-CVAD and/or autologous stem-cell transplant (ASCT) have produced 3-year OS rates >80%, prompting many to adopt their use. We evaluated outcomes from a single-center cohort managed in a more traditional fashion. We identified patients with MCL evaluated at Weill Cornell Medical Center since 1997, and included those with known date of diagnosis. An online social security database was used to verify survival. We identified 181 patients with MCL, and date of diagnosis could be determined in 111. Three-year OS from diagnosis was 86% [95% confidence interval (CI) 78% to 92%]. Median OS was 7.1 years (95% CI 63-98 months). Adequate information on therapy was available for 75 patients. Only five were treated upfront with (R)-Hyper-CVAD or ASCT while an additional four patients received one of these regimens subsequently. Treatment type had no significant effect on OS. Outcomes with standard approaches can yield similar survival to that achieved with more intensive approaches. Biases may account for the perceived superiority of aggressive strategies.

publication date

  • July 2008

has subject area

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Biomarkers, Tumor
  • Clinical Trials as Topic
  • Cohort Studies
  • Combined Modality Therapy
  • Cyclophosphamide
  • Databases, Factual
  • Dexamethasone
  • Disease-Free Survival
  • Doxorubicin
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Lymphoma, Mantle-Cell
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prednisone
  • Radiotherapy
  • Regression Analysis
  • Retrospective Studies
  • Rituximab
  • Stem Cell Transplantation
  • Survival Analysis
  • Time Factors
  • Transplantation, Autologous
  • Treatment Outcome
  • Vincristine

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/annonc/mdn045

PubMed ID

  • 18349031

Additional Document Info

start page

  • 1327

end page

  • 1330

volume

  • 19

number

  • 7