Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQ01 in patients who developed anthracycline-related congestive heart failure after childhood cancer Academic Article uri icon

Overview

MeSH Major

  • Alcohol Oxidoreductases
  • Anthracyclines
  • Heart Failure
  • NAD(P)H Dehydrogenase (Quinone)
  • Neoplasms
  • Polymorphism, Genetic

abstract

  • The functional CBR3 V244M polymorphism may have an impact on the risk of anthracycline-related CHF among childhood cancer survivors by modulating the intracardiac formation of cardiotoxic anthracycline alcohol metabolites. Larger confirmatory case-control studies are warranted.

publication date

  • June 15, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.23534

PubMed ID

  • 18457324

Additional Document Info

start page

  • 2789

end page

  • 95

volume

  • 112

number

  • 12