Regulation of hepatic lipogenesis by the transcription factor XBP1 Academic Article uri icon

Overview

MeSH Major

  • DNA-Binding Proteins
  • Fatty Acids
  • Lipogenesis
  • Liver
  • Nuclear Proteins

abstract

  • Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver. XBP1 protein expression in mice was elevated after feeding carbohydrates and corresponded with the induction of critical genes involved in fatty acid synthesis. Inducible, selective deletion of XBP1 in the liver resulted in marked hypocholesterolemia and hypotriglyceridemia, secondary to a decreased production of lipids from the liver. This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias.

publication date

  • June 13, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3620093

Digital Object Identifier (DOI)

  • 10.1126/science.1158042

PubMed ID

  • 18556558

Additional Document Info

start page

  • 1492

end page

  • 6

volume

  • 320

number

  • 5882