MeCP2, a key contributor to neurological disease, activates and represses transcription Academic Article uri icon


MeSH Major

  • Gene Expression Regulation
  • Hypothalamic Diseases
  • Hypothalamus
  • Methyl-CpG-Binding Protein 2
  • Nervous System Diseases


  • Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of function as well as increased dosage of the MECP2 gene cause a host of neuropsychiatric disorders. To explore the molecular mechanism(s) underlying these disorders, we examined gene expression patterns in the hypothalamus of mice that either lack or overexpress MeCP2. In both models, MeCP2 dysfunction induced changes in the expression levels of thousands of genes, but unexpectedly the majority of genes (approximately 85%) appeared to be activated by MeCP2. We selected six genes and confirmed that MeCP2 binds to their promoters. Furthermore, we showed that MeCP2 associates with the transcriptional activator CREB1 at the promoter of an activated target but not a repressed target. These studies suggest that MeCP2 regulates the expression of a wide range of genes in the hypothalamus and that it can function as both an activator and a repressor of transcription.

publication date

  • May 30, 2008



  • Academic Article



  • eng

PubMed Central ID

  • PMC2443785

Digital Object Identifier (DOI)

  • 10.1126/science.1153252

PubMed ID

  • 18511691

Additional Document Info

start page

  • 1224

end page

  • 9


  • 320


  • 5880