Gallium-transferrin as a macromolecular tracer of vascular permeability Academic Article Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal, Murine-Derived
  • Lymphoma, Follicular
  • Radioimmunotherapy
  • T-Lymphocyte Subsets
  • T-Lymphocytes

abstract

  • Labeling of plasma transferrin with gallium was investigated to determine whether the gallium-transferrin complex could be effectively used as a macromolecular tracer in studies of capillary permeability using Positron Emission Tomography (PET). Three gallium-plasma preparations were tested and 2 h biodistribution studies were performed in rats. The three preparations gave similar blood clearance and tissue distribution data, but the methods used for evaluating gallium-transferrin binding were found to be suboptimal. Gallium clearance from blood was biexpoential with both components faster than that of 125I-albumin. Gallium distribution spaces in all tissues including intracerebral Walker-256 tumors were larger than those of albumin. These results indicate a relative instability of the gallium-transferrin complex in vivo, which appears to preclude its use as an acceptable radiolabeled protein for vascular permeability studies using PET.

publication date

  • January 1988

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0883-2897(88)90059-1

PubMed ID

  • 3266964

Additional Document Info

start page

  • 665

end page

  • 72

volume

  • 15

number

  • 6