microRNA-7 inhibits the epidermal growth factor receptor and the akt pathway and is down-regulated in glioblastoma Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma
  • MicroRNAs
  • Proto-Oncogene Proteins c-akt

abstract

  • microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.

publication date

  • May 15, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-07-6639

PubMed ID

  • 18483236

Additional Document Info

start page

  • 3566

end page

  • 72

volume

  • 68

number

  • 10