Retinoic acid slows progression and promotes apoptosis of spontaneous prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Antineoplastic Agents
  • Apoptosis
  • Prostatic Neoplasms
  • Tretinoin

abstract

  • Collectively, our in vitro and in vivo data demonstrates that ATRA was able to slow prostate tumor cell proliferation, induce apoptosis, and block the emergence of the neuroendocrine phenotype. Furthermore, our study suggests the differential regulation of p21 and p27 as a molecular mechanism whereby ATRA intervention therapy can inhibit the natural history of spontaneous prostate cancer.

publication date

  • October 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pros.20097

PubMed ID

  • 15305337

Additional Document Info

start page

  • 142

end page

  • 52

volume

  • 61

number

  • 2