Defying the economists: A decrease in heart rate improves not only cardiac but also endothelial function Academic Article uri icon


MeSH Major

  • Benzazepines
  • Cardiotonic Agents
  • Heart Rate


  • Ivabradine has proven therapeutic efficacy for cardiac ischaemia and, until proved otherwise, is a very specific inhibitor of the cardiac sinoatrial node I(f) current. In the current issue of the British Journal of Pharmacology, Drouin et al. demonstrated that chronic treatment of the human apoB-100 transgene dyslipidaemic mouse with ivabradine significantly improved endothelium-dependent vasodilatation to ACh in renal and cerebral arteries and that the beneficial effects of ivabradine result secondarily to the lowering of heart rate. These data suggest that drugs that target the I(f) current have potential benefits not only as anti-ischaemics but also as agents for the treatment of endothelial dysfunction.

publication date

  • June 21, 2008



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1038/bjp.2008.168

PubMed ID

  • 18438420

Additional Document Info

start page

  • 727

end page

  • 8


  • 154


  • 4