Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection. Academic Article Article uri icon

Overview

MeSH

  • Biomarkers
  • Female
  • Humans
  • Immunoassay
  • Male
  • Middle Aged
  • ROC Curve
  • Sensitivity and Specificity

MeSH Major

  • Aneurysm, Dissecting
  • Aortic Aneurysm
  • Calcium-Binding Proteins
  • Microfilament Proteins

abstract

  • The early diagnosis of acute aortic dissection (AD) remains challenging. We sought to determine the utility of the troponin-like protein of smooth muscle, calponin, as a diagnostic biomarker of acute AD. Immunoassays against calponin (acidic, basic, and neutral isoforms) were developed and the levels were compared in a convenience sample of 59 patients with radiographically proven AD [34 males, age 59 +/- 15 (SD) years] vs. 158 patients suspected of having AD at presentation (116 males, age 63 +/- 15 years) but whose final diagnosis was not AD. Basic calponin, which is the most specific and abundant in smooth muscle, and acidic calponin, respectively, showed greater than two-fold and three-fold elevations in patients with acute AD. Diagnostic performance as determined by receiver-operating characteristics curve analysis showed that both acidic and basic calponin have the potential to detect AD in the first 24 h [respective areas under the curve (AUCs) 0.63 and 0.58], with superior performance of basic calponin (when compared with acidic) in the initial 6 h (respective AUCs 0.63 and 0.67). Circulating calponin levels were elevated in acute AD compared with controls. These biomarkers have the potential for use as an early diagnostic biomarker for acute AD.

publication date

  • June 2008

has subject area

  • Aneurysm, Dissecting
  • Aortic Aneurysm
  • Biomarkers
  • Calcium-Binding Proteins
  • Female
  • Humans
  • Immunoassay
  • Male
  • Microfilament Proteins
  • Middle Aged
  • ROC Curve
  • Sensitivity and Specificity

Research

keywords

  • Journal Article
  • Multicenter Study

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1093/eurheartj/ehn162

PubMed ID

  • 18436559

Additional Document Info

start page

  • 1439

end page

  • 1445

volume

  • 29

number

  • 11