Pathogenic role of antiphospholipid antibodies Review uri icon

Overview

MeSH Major

  • Antibodies, Antiphospholipid

abstract

  • The antiphospholipid antibody syndrome (APS) is characterized by recurrent arterial and venous thrombosis and/or pregnancy in association with antiphospholipid (aPL) antibodies. The pathogenic mechanisms in APS that lead to in vivo injury are incompletely understood. Recent evidence suggests that APL antibodies alter regulation of haemostasis and induce activation of complement. We will discuss the current knowledge on how aPL antibodies trigger increased inflammation and enhanced thrombotic tendency, and thereby lead to tissue damage.

publication date

  • June 13, 2008

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2693020

Digital Object Identifier (DOI)

  • 10.1177/0961203308090025

PubMed ID

  • 18490417

Additional Document Info

start page

  • 405

end page

  • 11

volume

  • 17

number

  • 5 SPEC. ISS.