The innate immune system in SLE: Type I interferons and dendritic cells Review uri icon

Overview

MeSH Major

  • Dendritic Cells
  • Immune System
  • Immunity, Innate
  • Interferon Type I
  • Lupus Erythematosus, Systemic

abstract

  • Patients with systemic lupus erythematosus (SLE) have an increased expression of type I interferon (IFN) regulated genes because of a continuous production of IFN-alpha. The cellular and molecular background to this IFN-alpha production has started to be elucidated during the last years, as well as the consequences for the innate and adaptive immune systems. Plasmacytoid dendritic cells (pDC) activated by immune complexes containing nucleic acids secrete type I IFN in SLE. Type I IFN causes differentiation of monocytes to myeloid-derived dendritic cell (mDC) and activation of autoreactive T and B cells. A new therapeutic option in patients with SLE is, therefore, inhibition of IFN-alpha, and recent data from a phase I clinical trial suggests that administration of neutralizing monoclonal antibodies against anti-IFN-alpha can ameliorate disease activity.

publication date

  • June 13, 2008

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3694565

Digital Object Identifier (DOI)

  • 10.1177/0961203308090020

PubMed ID

  • 18490415

Additional Document Info

start page

  • 394

end page

  • 9

volume

  • 17

number

  • 5 SPEC. ISS.