Prognostic indicators of malignancy in adrenal pheochromocytomas: clinical, histopathologic, and cell cycle/apoptosis gene expression analysis Academic Article uri icon

Overview

MeSH Major

  • Adrenal Gland Neoplasms
  • Apoptosis
  • Cell Cycle
  • Gene Expression Regulation, Neoplastic
  • Neoplasm Recurrence, Local
  • Pheochromocytoma

abstract

  • (1) A PASS score of <4 predicted benign pheochromocytomas. (2) All malignant pheochromocytomas had a PASS score >/=6, which was significantly higher compared with the benign lesions. Patients with a PASS score >/=4 should be followed closely for recurrence. (3) p53, Bcl-2, mdm-2, cyclin D1, p21, and p27 appear to have no role in predicting the behavior of pheochromocytomas. Ki-67 may help identify those neoplasms at risk for recurrence by prompting the pathologist to look aggressively for adverse histologic features.

publication date

  • June 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.surg.2008.02.007

PubMed ID

  • 18549892

Additional Document Info

start page

  • 759

end page

  • 68

volume

  • 143

number

  • 6