Prostaglandin E2 inhibits transforming growth factor β1-mediated induction of collagen α1(I) in hepatic stellate cells Academic Article uri icon

Overview

MeSH Major

  • Collagen Type I
  • Dinoprostone
  • Liver
  • Transforming Growth Factor beta

abstract

  • These results suggest that COX-2-derived PGE(2) inhibits both basal and TGF-beta 1-mediated induction of collagen synthesis by HSC. Based on these findings, it will be important to determine whether inhibiting COX-derived PGE(2) synthesis alters the progression of liver fibrosis in vivo.

publication date

  • August 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jhep.2004.04.033

PubMed ID

  • 15288474

Additional Document Info

start page

  • 251

end page

  • 8

volume

  • 41

number

  • 2