Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: A report from the childhood cancer survivor study Academic Article uri icon


MeSH Major

  • Cranial Irradiation
  • Obesity
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Receptors, Cell Surface


  • Female survivors with BMI > or = 25 kg/m2 were more likely Arg homozygous than those with BMI less than 25 kg/m2 (24% v 12%; P =.007). This difference was not observed in males. Moreover, among females treated with > or = 20 Gy cranial radiation, Arg/Arg individuals had six times higher odds of having BMI > or = 25 kg/m2 (95% CI, 2.1 to 22.0) than those with a Gln allele (P =.04 for interaction). CONCLUSION LEPR polymorphism may influence obesity in female survivors of childhood ALL, particularly those exposed to cranial radiation. Because obesity is associated with increased morbidity and mortality in later life, identification of children at high risk might allow for early targeted interventions.

publication date

  • December 2004



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2004.11.152

PubMed ID

  • 15337805

Additional Document Info

start page

  • 3558

end page

  • 62


  • 22


  • 17