Involvement of the serotonin 5-HT2Breceptor in cardiac hypertrophy linked to sympathetic stimulation: Control of interleukin-6, interleukin-1β, and tumor necrosis factor-α cytokine production by ventricular fibroblasts Academic Article uri icon

Overview

MeSH Major

  • Cardiomegaly
  • Fibroblasts
  • Indoles
  • Myocytes, Cardiac
  • Pyridines
  • Quinolines
  • Receptor, Serotonin, 5-HT2B
  • Serotonin Antagonists
  • Sympathetic Nervous System

abstract

  • Our results demonstrate for the first time that 5-HT2B receptors are essential for isoproterenol-induced cardiac hypertrophy, which involves the regulation of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by cardiac fibroblasts.

publication date

  • August 24, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000139856.20505.57

PubMed ID

  • 15302781

Additional Document Info

start page

  • 969

end page

  • 74

volume

  • 110

number

  • 8