Epratuzumab in non-Hodgkin's lymphomas. Article Review uri icon

Overview

MeSH

  • Antibodies, Monoclonal, Humanized
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Maximum Tolerated Dose
  • Neoplasm Staging
  • Prognosis
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome

MeSH Major

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Lymphoma, Non-Hodgkin

abstract

  • Non-Hodgkin's lymphomas (NHL) are a diverse group of malignancies that result, in addition to their treatments, in significant morbidity and mortality in the population. The identification of more effective and better tolerated treatments is of vital importance. Immunotherapy using monoclonal antibodies directed against the CD20 protein has had a profound impact on the management of patients with B-cell NHL. Additional antigen targets are being aggressively investigated. The targeting of lymphoma cells with monoclonal antibodies offers a treatment with a potentially noncross-resistant mechanism of action and a more favorable toxicity profile compared to chemotherapy. Epratuzumab (humanized LL2) is a humanized immunoglobulin G1 monoclonal antibody directed against the CD22 protein in which expression is restricted to mature B cells. Because of important differences in the characteristics of CD22 compared to CD20, epratuzumab may become an important component of future therapies for NHL.

publication date

  • August 2004

has subject area

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Infusions, Intravenous
  • Lymphoma, Non-Hodgkin
  • Male
  • Maximum Tolerated Dose
  • Neoplasm Staging
  • Prognosis
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome

Research

keywords

  • Comparative Study
  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 15233905

Additional Document Info

start page

  • 283

end page

  • 288

volume

  • 5

number

  • 4