A Sweet New Role for EGFR in Cancer Article uri icon

Overview

MeSH Major

  • Neoplasms
  • Receptor, Epidermal Growth Factor

abstract

  • The epidermal growth factor (EGFR) has served as an attractive bull's-eye for targeted cancer therapies. Although the importance of EGFR as an oncogenic tyrosine kinase seems well established, a report by Weihua et al. in this issue of Cancer Cell adds a new wrinkle to the role of EGFR in cancer. In this study, the authors demonstrate that EGFR facilitates glucose transport into cells by associating with and stabilizing a sodium/glucose cotransporter (SGLT1). Additionally, they find that this function does not require EGFR kinase activity. These results point to a new kinase-independent role for EGFR in promoting metabolic homeostasis in cancer cells.

publication date

  • May 6, 2008

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2008.04.008

Additional Document Info

start page

  • 375

end page

  • 6

volume

  • 13

number

  • 5