Suppressing PTEN activity by tobacco smoke plus interleukin-1β modulates dissociation of VE-cadherin/β-catenin complexes in endothelium Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD
  • Cadherins
  • Endothelium, Vascular
  • Interleukin-1beta
  • PTEN Phosphohydrolase
  • Smoke
  • Tobacco
  • beta Catenin

abstract

  • TS interaction with IL-1beta modulates PTEN activity though the ROS/Src/EGFR-p38MAPK pathway. PTEN deactivation is essential to increase VE-cadherin and beta-catenin p-Tyr and to disassemble VE-cadherin/beta-catenin membrane complexes, events that lead to accumulation of beta-catenin within the nucleus.

publication date

  • April 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.107.159434

PubMed ID

  • 18202321

Additional Document Info

start page

  • 732

end page

  • 8

volume

  • 28

number

  • 4