Retinoic acid receptor γ activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells Academic Article uri icon

Overview

MeSH Major

  • Embryonal Carcinoma Stem Cells
  • GATA4 Transcription Factor
  • Receptor, TIE-1
  • Receptors, Retinoic Acid
  • Transcription, Genetic

abstract

  • Our results indicate that GATA4 plays a role in the RA/RARgamma-associated transcriptional activation of the Tie1 promoter. An understanding of RAR specificity in RA signaling should result in insights into hematopoietic stem cell signaling and potentially in improved therapies for several human diseases.

publication date

  • May 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2007.12.016

PubMed ID

  • 18439490

Additional Document Info

start page

  • 624

end page

  • 41

volume

  • 36

number

  • 5