Dendritic cells are required for effective cross-presentation in the murine liver
Academic Article
Overview
MeSH Major
Cross-Priming
Dendritic Cells
Liver
T-Lymphocytes
abstract
Our findings indicate that the ability of the liver to effectively cross-present soluble protein to antigen-specific CD8(+) T cells depends primarily on cDCs. Despite costimulation, other resident liver antigen-presenting cells cannot compensate for the absence of cDCs.
