Negative influence of changing biopsy practice patterns on the predictive value of prostate-specific antigen for cancer detection on prostate biopsy Academic Article uri icon

Overview

MeSH Major

  • Biopsy
  • Practice Patterns, Physicians'
  • Prostate-Specific Antigen
  • Prostatic Neoplasms

abstract

  • Early in the PSA era, the predictive power of PSA depended on multiple factors: high prevalence of disease, higher prevalence of high-grade disease, and low likelihood of prostate cancer diagnosis in men with low PSA. Now, beyond the culling effect of increased biopsy incidence and with shifted biopsy practice patterns, the correlation between PSA and biopsy result is lost in men with normal DRE. Diagnosing a higher proportion of tumors in men with a PSA between 2.0-4.0 ng/mL has negatively influenced the predictive value of PSA for cancer detection.

publication date

  • April 15, 2008

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.23353

PubMed ID

  • 18330908

Additional Document Info

start page

  • 1718

end page

  • 25

volume

  • 112

number

  • 8